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Phosphatidylinositol-3-kinase signaling mediates vascular smooth muscle cell expression of periostin in vivo and in vitro

✍ Scribed by Guohong Li; Suzanne Oparil; John M. Sanders; Lin Zhang; Meiru Dai; Lan Bo Chen; Simon J. Conway; Coleen A. McNamara; Ian J. Sarembock

Book ID: 118421052
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 584 KB
Volume: 188
Category: Article
ISSN: 0021-9150
DOI: 10.1016/j.atherosclerosis.2005.11.002

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## Abstract To dissect the effect of hyperinsulinemia versus hyperglycemia on TNF‐related apoptosis inducing ligand (TRAIL) expression in the macrovascular district, we measured TRAIL mRNA and protein in four groups of animals: streptozotocin (SZT)‐induced diabetic rats, vehicle‐treated control ani