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Phosphatidylinositol 3-kinase is required for platelet-derived growth factor's actions on hepatic stellate cells

✍ Scribed by F Marra; A Gentilini; M Pinzani; GG Choudhury; M Parola; H Herbst; MU Dianzani; G Laffi; HE Abboud; P Gentilini

Book ID
118519838
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
448 KB
Volume
112
Category
Article
ISSN
0016-5085

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Upon liver injury, hepatic stellate cells (HSC) show increased proliferation, motility, and extracellular matrix (ECM) production. The extracellular signal-regulated kinases (ERK) control different functions in a cell-specific manner. In this study, we evaluated the role of ERK activation in culture