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Phosphatidylinositol 3-kinase-dependent transcriptional silencing of the translational repressor 4E-BP1

✍ Scribed by R. Azar; S. Najib; H. Lahlou; C. Susini; S. Pyronnet

Book ID: 105758854
Publisher: Springer
Year: 2008
Tongue: English
Weight: 755 KB
Volume: 65
Category: Article
ISSN: 1420-682X
DOI: 10.1007/s00018-008-8418-2

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## Abstract PHosphate‐regulating gene with homology to Endopeptidase on the X chromosome (PHEX) has been identified as the gene mutated in X‐linked hypophosphatemia (XLH) syndrome, the most prevalent form of rickets in humans. The predominant expression of __PHEX__ in bones and teeth, and the defec