✦ LIBER ✦

Phosphatidyl inositol isopropylidene derivatives: synthesis, characterizaton and use as synthetic intermediates

✍ Scribed by Naoki Noda; Roy W. Keenan

Book ID: 103040926
Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 783 KB
Volume: 53
Category: Article
ISSN: 0009-3084
DOI: 10.1016/0009-3084(90)90133-c

No coin nor oath required. For personal study only.

✦ Synopsis

To provide starting material for the synthesis of phosphatidyl inositol phosphates and inositol phosphates, isopropylidenes of phosphatidyl inositols were prepared. Phosphatidyl inositol obtained from yeast was converted into a mono-and two di-O-isopropylidenes fractions by transacetalation with 2,2-dimethoxypropane. Three isopropylidenes fractions were isolated and characterized by mass spectral analysis and comparison of the hydrolysis products of these fractions to know isopropylidenes of myo-inositol. The isopropylidenes were phosphatidtyl-2,3-O-isopropylidene-inositois, phosphatidyl-2,3:4,5-di-O-isopropylideneinositols and phosphatidyl-2,3:5,6-di-O-isopropylidene-inositols. These compounds are intermediates for the stereospecifie synthesis of different phosphatidyl inositol phosphates, inositol phosphates and analogs of these compounds. Using the di-O-isopropylidenes as starting materials, both phosphatidyl inositol-4-phosphate and phosphatidyl inositoi-6-phosphates were synthesized. Neither compound had been prepared synthetically before and phosphatidyl inositol-6-phosphate is not naturally occurring.

📜 SIMILAR VOLUMES

Synthetic intermediates potentially usef

Synthetic intermediates potentially useful for the synthesis of tetrodotoxin and derivatives

✍ Keana, John F. W.; Mason, Franklin P.; Bland, Jeffrey S. 📂 Article 📅 1969 🏛 American Chemical Society 🌐 English ⚖ 456 KB

Synthetic Studies of Substituted Pyridin

Synthetic Studies of Substituted Pyridine Aldehydes as Intermediates for the Synthesis of Toddaquinoline, Its Derivatives and Other Natural Products

✍ Serban, Georgeta; Abe, Hitoshi; Takeuchi, Yasuo 📂 Article 📅 2011 🏛 Japan Institute of Heterocyclic Chemistry 🌐 English ⚖ 689 KB

Synthetic intermediates potentially usef

Synthetic intermediates potentially useful for the synthesis of tetrodotoxin and derivatives. II. Reaction of diazomethane with some shikimic acid derivatives

✍ Keana, John F. W.; Kim, Choung U. 📂 Article 📅 1970 🏛 American Chemical Society 🌐 English ⚖ 571 KB

ChemInform Abstract: Derivatives of 7-Ox

ChemInform Abstract: Derivatives of 7-Oxabicyclo[2.2.1]heptane in Nature and as Useful Synthetic Intermediates

✍ Pierre Vogel; Janine Cossy; Joaquin Plumet; Odon Arjona 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 26 KB 👁 1 views

Enantiomerically pure 7-oxabicylo[2.2.1]

Enantiomerically pure 7-oxabicylo[2.2.1]hept-5-en-zyl derivatives as synthetic intermediates. Part III. Total synthesis of D- and L-ribose derivatives

✍ Jürgen Wagner; Eric Vieira; Pierre Vogel 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 German ⚖ 554 KB

4, ## Experimental Part 1. General. Solvents were either reagent or technical grade and when necessary were purified and dried by distillation from an appropriate dessiccant under N,. S o h . after reactions and extractions were evaporated at ca. 20 Torr. HMPA = hexamethylphosphoric triamide. M.p

Synthetic intermediates potentially usef

Synthetic intermediates potentially useful for the synthesis of tetrodotoxin and derivatives. 8. A series of highly functionalized pyrimidinones

✍ Keana, John F. W.; Boyle, Patrick J.; Erion, Mark; Hartling, Ross; Husman, James 📂 Article 📅 1983 🏛 American Chemical Society 🌐 English ⚖ 830 KB