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Phosphatidic acid and lysophosphatidic acid stimulate receptor-regulated membrane currents in the Xenopus laevis oocyte

โœ Scribed by James E. Ferguson; Michael R. Hanley

Book ID
115709325
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
517 KB
Volume
297
Category
Article
ISSN
0003-9861

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In Xenopus oocytes, both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) activate Ca2+-dependent oscillatory Cl- currents by acting through membrane-bound receptors. External application of 50 microM S1P elicited a long-lasting oscillatory current that continued over 30 min from the be