Phorbol esters down-regulate alpha-fetoprotein gene expression without affecting growth in fetal hepatocytes in primary culture
✍ Scribed by César Roncero; Juan-José Ventura; Aránzazu Sánchez; Brigitte Bois-Joyeux; M.Luisa Mesa; Hélène Thomassin; Jean-Louis Danan; Manuel Benito; Isabel Fabregat
- Book ID
- 117350954
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 513 KB
- Volume
- 1402
- Category
- Article
- ISSN
- 0167-4889
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The culture of fetal hepatocytes for 64 h in medium supplemented with 5 mM glucose, T3, insulin, and dexamethasone resulted in the coordinate precocious expression of malic enzyme mRNA, protein, and specific activity. T3 was the main inducer; meanwhile, insulin exerted a small synergist
Fetal rat hepatocytes incubated in the absence of hormonal signals, or under proliferative (presence of epidermal growth factor [EGF]) or differentiative (presence of dexamethasone) culture conditions, showed responsiveness to interleukin-6 (IL-6). Northern blotting analysis for some typical acute p