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Phorbol esters can persistently replace interleukin-3 (IL-3) for the growth of a IL-3-dependent cell line


Book ID
123129092
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
165 KB
Volume
1
Category
Article
ISSN
1043-4666

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Phorbol esters can persistently replace
โœ Toshikazu Takeshita; Yuso Goto; Masataka Nakamura; Masahiro Fujii; Masafumi Iwam ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 799 KB

A selected clone from an IL-2-dependent human T-cell line was persistently propagated in the presence of phorbol esters with the ability to activate protein kinase C (PKC), such as 12-0-tetradecanoylphorbol-I 3-acetate (TPA) or phorbol-12,1.3-dibutylate (PDBu). Thus, a TPA(PD6u)-dependent T-cell lin