The response of rat hepatocytes to hormones and growth factors has been extensively studied with respect to phospholipase regulation and calcium mobilization. However, the mitogen-activated protein (MAP) kinase cascade which integrates signals from a wide variety of extracellular stimuli has not bee
β¦ LIBER β¦
Phorbol esters, but not epidermal growth factor or insulin, rapidly decrease soluble protein kinase C activity in rat hepatocytes
β Scribed by W.J. Vaartjes; C.G.M. de Haas; S.G. van den Bergh
- Book ID
- 117057218
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 391 KB
- Volume
- 138
- Category
- Article
- ISSN
- 0006-291X
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The role of diacylglycerol (DAG) in hormonal induction of S phase was investigated in primary cultures of rat hepatocytes. In this model, several agonists that bind to G protein-coupled receptors act as comitogens when added to the cells soon after plating (i.e., in Go/early Gl phase), while the cel