✦ LIBER ✦

Phorbol Ester-Induced Tumor Promotion by Downregulation of Protein Kinase C

✍ Scribed by K. A. Droms; A. M. Malkinson

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 185 KB
Volume: 4
Category: Article
ISSN: 0899-1987
DOI: 10.1002/mc.2940040102

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Evidence against a role of general prote

Evidence against a role of general protein kinase C downregulation in skin tumor promotion

✍ Simone Manzow; Karl Hartmut Richter; Luise Stempka; Gerhard Fürstenberger; Fried 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 101 KB

Using isoenzyme-specific antibodies, we have performed an immunoblot analysis of the PKC isoenzyme pattern during the course of TPA-induced tumor promotion in the epidermis of NMRI mice. The TPA-sensitive PKC isoforms alpha, delta, straightepsilon, eta, nu (and TPA-insensitive PKCzeta), but not PKCb

Calphostin C induces tyrosine dephosphor

Calphostin C induces tyrosine dephosphorylation/inactivation of protein kinase Fa/GSK-3α in a pathway independent of tumor promoter phorbol ester-mediated down-regulation of protein kinase C

✍ Shan-Chih Lee; Shiaw-Der Yang 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 950 KB

The signal transduction mechanism of protein kinase FA/GSK-3a by tyrosine phosphorylation in A431 cells was investigated using calphostin C as an inhibitor for protein kinase C (PKC). Kinase F A / C S K -~~ could be tyrosine-dephosphorylated and inactivated to -10% of control in a concentration-depe

Eyes wide shut: Protein kinase C isozyme

Eyes wide shut: Protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters

✍ Marcelo G. Kazanietz 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 103 KB

In addition to the well-characterized interaction with classical and novel protein kinase C (PKC) isozymes, the phorbol ester tumor promoters bind to other receptors lacking kinase activity. Among these novel phorbol ester receptors, two families of proteins may play a role in the regulation of cell

Protein kinase C β1 overexpression augme

Protein kinase C β1 overexpression augments phorbol ester-induced increase in endothelial permeability

✍ Pablito G. Nagpala; Asrar B. Malik; Phuoc T. Vuong; Hazel Lum 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 438 KB

We studied the postulated involvement of the protein kinase C P1 (PKCP, 1 isoform in the regulation of endothelial permeability using human dermal microvascular endothelial cell line (HMEC-1). We overexpressed the recombinant PKCP, gene via retroviral-mediated transduction in these cells. PKCP, gene

Distribution of protein kinase C in the

Distribution of protein kinase C in the brain ofApteronotus leptorhynchusas revealed by phorbol ester binding

✍ Maler, Leonard 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 358 KB 👁 2 views

An antibody to the mammalian protein kinase C alpha (PKCalpha) subunit and brain dissection was used for immunoblot analysis of this protein in various brain regions of Apteronotus leptorhynchus. Western blots revealed that the antibody labeled a band of the expected molecular mass (approximately 80

ChemInform Abstract: Structural Basis of

ChemInform Abstract: Structural Basis of Protein Kinase C Activation by Tumor Promoters

✍ Y. KISHI; R. R. RANDO 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 24 KB 👁 2 views