We have shown previously that the tumor promoter phorbol myristate acetate (PMA) induces capillary endothelial cells grown on t h e surface of threedimensional collagen gels to invade the underlying matrix as capillary-like tubular structures, a phenomenon mimicking angiogenic processes that oc- cur
Phorbol ester-induced hairy cell features on chronic lymphocytic leukemia cells in vitro
β Scribed by Ayad Ai-Katib; Chang Yi Wang; Susan McKenzie; Bayard D. Clarkson; Benjamin Koziner
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 538 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0361-8609
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Leukemic cells from ten patients with "nonsecretory," B-type chronic lymphocytic leukemia (CLL) were cultured alone or in the presence of Epstein-Barr virus (EBV) or a phorbol ester (12-0-tetradecanoylphorbol-13-acetate; TPA) for 7 days. At periodic intervals the cell morphology, cytoplasmic immunog
## Abstract Peripheral blood T cells from a patient with Tβcell chronic lymphocytic leukemia (TβCLL) failed to respond to mitogenic lectins or alloantigens but could be induced to proliferate by the addition of exogenous interleukinβ2 (ILβ2). The TβCLL cells also proliferated in response to 12β__O_