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PHO85, a negative regulator of the PHO system, is a homolog of the protein kinase gene, CDC28, of Saccharomyces cerevisiae

✍ Scribed by Toh-e, Akio ;Tanaka, Kazuma ;Uesono, Yukifumi ;Wickner, Reed B.

Book ID
104730045
Publisher
Springer
Year
1988
Tongue
English
Weight
266 KB
Volume
214
Category
Article
ISSN
0026-8925

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✦ Synopsis

The product of the PHO85 gene, which encodes one of the negative regulatory factors of the PHO system in Saccharomyces cerevisiae, shows significant amino acid sequence homology with the CDC28 protein kinase. However, overexpressing PHO85 did not suppress the temperature sensitive phenotype of the cdc28-1 mutation. The nucleotide sequence of the PHO85 gene strongly suggests the presence of an intron near the sequence encoding the N-terminal region.

πŸ“œ SIMILAR VOLUMES

The KNS1 gene of Saccharomyces cerevisia
The KNS1 gene of Saccharomyces cerevisiae encodes a nonessential protein kinase homologue that is distantly related to members of the CDC28/cdc2 gene family
✍ Padmanabha, Ramesh ;Gehrung, Sonja ;Snyder, Michael πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 972 KB

A novel protein kinase homologue (KNS1) has been identified in Saccharomyces cerevisiae. KNS1 contains an open reading frame of 720 codons. The carboxy-terminal portion of the predicted protein sequence is similar to that of many other protein kinases, exhibiting 36% identity to the cdc2 gene produc