## Abstract This report describes a chronic myelogenous leukaemia patient with an apparently normal bone marrow karyotype but __BCR/ABL__ fusion‐gene‐positive. Commercial FISH probes showed an atypical pattern and the __BCR/ABL__ fusion transcript was detected by RT‐PCR, but not the reciprocal __AB
✦ LIBER ✦
Philadelphia-negative chronic myeloid leukaemia: detection by FISH of BCR-ABL fusion gene localized either to chromosome 9 or chromosome 22
✍ Scribed by E. Nacheva; T. Holloway; K. Brown; D. Bloxham; A. R. Green
- Book ID
- 114713734
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 353 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0007-1048
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## Abstract Leukemic cells from two patients with Philadelphia‐negative chronic myeloid leukemia (CML) were investigated: I) Cytogenetics showed a normal 46.XY karyotype in both cases, 2) molecular studies revealed rearrangement of the M‐BCR region and formation of __BCR‐ABL__ fusion mRNA with b2a2