Philadelphia chromosome without breakpoint cluster region rearrangement in a case of Lennert's lymphoma of suppressor phenotype

✍ Scribed by Terenig Terjanian; Mark B. Blick; Mordechai Shtalrid; John T. Manning; Jose M. Trujillo; Dr. Fernando Cabanillas

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 635 KB
• Volume: 7
• Category: Article
• ISSN: 0278-0232
• DOI: 10.1002/hon.2900070302

✦ Synopsis

A 60-year-old woman presented with diffuse lymphadenopathy. Diagnostic and staging work-up showed that the patient had diffuse small cleaved cell lymphoma (diffuse poorly differentiated lymphocytic lymphoma) with associated histiocytes (lymphoepithelioid cell lymphoma) by the Kiel classification system. Immunohistologic staining showed a T suppressor cell tumour phenotype. Cytogenetic studies revealed the Philadelphia chromosome (Ph'). On DNA studies, the breakpoint cluster region (BCR) gene was not rearranged suggesting that the Ph' involvement was not identical to that seen in chronic myelogenous leukemia (CML). This case is presented because of the rarity of Ph' in lymphoid malignancies, particularly in those of T-cell origin, and because of its potentially adverse implications.