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Phenytoin reversal and prevention of morphine-induced catalepsy in the rat

โœ Scribed by Susan L. Cookson; J.Douglas Mann


Book ID
113218212
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
370 KB
Volume
12
Category
Article
ISSN
0091-3057

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Subsensitivity to muscimol-induced catal
โœ Robert Lalonde; M. I. Botez ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› Springer ๐ŸŒ English โš– 440 KB

Male albino rats were injected with 25 mg/kg of phenytoin (PHT) every day for 20 consecutive days and were tested on days 21 and 28 for their response to 1 or 2 mg/kg of muscimol, a GABA receptor agonist. Rats treated with PHT showed a decreased responsiveness to muscimol-induced catalepsy (2 mg/kg)