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Phenytoin-Related cerebellar degeneration without seizures

✍ Scribed by Dr. Richard L. Rapport II; Cheng-Mei Shaw

Book ID
101462977
Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
314 KB
Volume
2
Category
Article
ISSN
0364-5134

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✦ Synopsis

Abstract

Cerebellar changes have been reported in relationship to epilepsy alone as well as to phenytoin therapy for the control of seizures. The cliniconeuropathological correlation between these changes and epilepsy or the anticonvulsant is usually complicated by the presence of both variables. Experimental evidence suggests that phenytoin alone may be sufficient to cause cerebellar changes following intoxication. We report a case of cerebellar degeneration in a patient treated with isoniazid and prophylactically treated with phenytoin who never had a seizure.

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