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Phenytoin pretreatment prevents hypoxic-ischemic brain damage in neonatal rats

✍ Scribed by Mark G. Vartanian; John J. Cordon; Nancy C. Kupina; Gerald P. Schielke; Avigail Posner; Kadee J. Raser; Kevin K.W. Wang; Charles P. Taylor


Book ID
113253287
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
956 KB
Volume
95
Category
Article
ISSN
0165-3806

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We examined the neuroprotective efficacy of a posttreatment with idazoxan (Idaz): an ␣2-adrenoceptor antagonist with activity at the I1-and I2-subtypes of the imidazoline receptor (I-receptor), in an experimental model of perinatal hypoxic-ischemic (HI) brain damage. Seventy-two, 7-day-old Wistar ra