Phenylethyl Glycosides from Globularia alypum Growing in Turkey

✍ Scribed by Hasan Kırmızıbekmez; Carla Bassarello; Sonia Piacente; İhsan çalış

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: German
• Weight: 199 KB
• Volume: 91
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200890166

✦ Synopsis

Abstract

From the leaves of Globularia alypum, three new phenylethyl glycosides, namely galypumosides A (=2‐(3,4‐dihydroxyphenyl)ethyl O‐α‐rhamnopyranosyl‐(1→3)‐4‐O‐[(E)‐caffeoyl]‐6‐O‐[(E)‐p‐coumaroyl]‐β‐glucopyranoside; 1), B (=2‐(3,4‐dihydroxyphenyl)ethyl O‐α‐rhamnopyranosyl‐(1→3)‐4‐O‐[(E)‐caffeoyl]‐6‐O‐[(E)‐feruloyl]‐β‐glucopyranoside; 2), and C (=2‐(3,4‐dihydroxyphenyl)ethyl O‐α‐rhamnopyranosyl‐(1→3)‐4‐O‐[(E)‐caffeoyl]‐6‐O‐menthiafoloyl‐β‐glucopyranoside; 3), were isolated, together with two known phenylethyl glycosides, calceolarioside A and verbascoside. Eight iridoid glucosides, catalpol, globularicisin, globularin, globularidin, globularinin, globularimin, lytanthosalin, and alpinoside, a flavon glycoside, 6‐hydroxyluteolin 7‐O‐sophoroside, a lignan glycoside, syringaresinol 4′‐O‐β‐glucopyranoside, and a phenylpropanoid glycoside, syringin, were also obtained and characterized. The structures of the isolates were elucidated on the basis of 1D‐ and 2D‐NMR experiments as well as HR‐MALDI‐MS.