Phenylbutazone as a therapeutic agent in rheumatic diseases: Its present status

Enzyme specificity and tissue distributi

Enzyme specificity and tissue distribution of zenarestat, an aldose reductase inhibitor, and its relevance in the use of zenarestat as a therapeutic agent against diabetic neuropathy

✍ Shoji Takakura; Hideaki Minoura; Yukinori Shimoshige; Kyoko Minoura; Ikuo Kawamu 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 146 KB

## Abstract The enzyme specificity and tissue distribution of zenarestat, an aldose reductase inhibitor, was investigated in diabetic rats. Zenarestat inhibited both rat sciatic nerve aldose reductase (AR) activity and recombinant human AR with IC~50~ values of 7.5 and 44 nM, respectively. However,