𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Phenylalanine Aminomutase-Catalyzed Addition of Ammonia to Substituted Cinnamic Acids: a Route to Enantiopure α- and β-Amino Acids

✍ Scribed by Szymanski, Wiktor; Wu, Bian; Weiner, Barbara; de Wildeman, Stefaan; Feringa, Ben L.; Janssen, Dick B.

Book ID
115507691
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
819 KB
Volume
74
Category
Article
ISSN
0022-3263

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Enzymatic Synthesis of Enantiopure α- an
Enzymatic Synthesis of Enantiopure α- and β-Amino Acids by Phenylalanine Aminomutase-Catalysed Amination of Cinnamic Acid Derivatives
✍ Bian Wu; Wiktor Szymanski; Piet Wietzes; Stefaan de Wildeman; Gerrit J. Poelaren 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 254 KB 👁 1 views

## Abstract The phenylalanine aminomutase (PAM) from __Taxus chinensis__ catalyses the conversion of α‐phenylalanine to β‐phenylalanine, an important step in the biosynthesis of the __N__‐benzoyl phenylisoserinoyl side‐chain of the anticancer drug taxol. Mechanistic studies on PAM have suggested th

Rhodium-catalyzed asymmetric addition of
Rhodium-catalyzed asymmetric addition of arylboronic acids to γ-phthalimido-substituted-α,β-unsaturated carboxylic acid esters: an approach to γ-amino acids
✍ Fuzhong Han; Jun Chen; Xiangyang Zhang; Jibing Liu; Linfeng Cun; Jin Zhu; Jingen 📂 Article 📅 2011 🏛 Elsevier Science 🌐 French ⚖ 412 KB

Efficient Rh-catalyzed asymmetric 1,4-addition of arylboronic acids to ethyl-c-phthalimidocrotonate by using bis-sulfoxide ligand affords c-aminobutyric acid (GABA) derivatives with high enantioselectivities (90-96% ee) under mild conditions. Optically pure (S)-Baclofen and (S)-Rolipram have been pr