Phenylalanine 445 within Oxidosqualene—Lanosterol Cyclase from Saccharomyces cerevisiae Influences C-Ring Cyclization and Deprotonation Reactions.

Histidine Residue at Position 234 of Oxi

Histidine Residue at Position 234 of Oxidosqualene-Lanosterol Cyclase from Saccharomyces cerevisiae Simultaneously Influences Cyclization, Rearrangement, and Deprotonation Reactions

✍ Tung-Kung Wu; Yuan-Ting Liu; Cheng-Hsian Chang 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 348 KB

Oxidosqualene cyclases catalyze the biotransformation of acyclic (3S)-2,3-oxidosqualene (OS) to a variety of polycyclic sterols and triterpenoids, generating over 100 distinct triterpenoid skeletons with the formula C 30 H 50 O. [1-3, 4 and references therein] Product specificity is species-dependen