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Phenotypic variation between parent–offspring trios and non-trios in genetic studies of schizophrenia

✍ Scribed by Stanley Zammit; Glyn Lewis; Anita Thapar; Richard Owen; Gaynor Jones; Susan Jones; Rob Sanders; Charis Milham; Ameera Mahdi; Michael C. O’Donovan; Michael J. Owen

Book ID
113750041
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
101 KB
Volume
40
Category
Article
ISSN
0022-3956

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## Abstract Traditional case‐control genetic association studies utilizing unrelated probands are often used interchangeably with family‐based designs to detect genes for complex psychiatric disorders. This strategy may be limited, however, if significant phenotypic variation exists between proband