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Phenotypic polymorphism of haptoglobin: A novel risk factor for the development of infection in liver cirrhosis

✍ Scribed by Zsuzsanna Vitalis; Istvan Altorjay; Istvan Tornai; Karoly Palatka; Sandor Kacska; Eszter Palyu; David Tornai; Miklos Udvardy; Jolan Harsfalvi; Tamas Dinya; Gabor Veres; Peter Laszlo Lakatos; Maria Papp


Book ID
116533076
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
1017 KB
Volume
72
Category
Article
ISSN
0198-8859

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Alpha(1)-antitrypsin deficiency (AATD) due to homozygosity of the protease inhibitor (Pi) Z variant predisposes to childhood liver disease and pulmonary emphysema. About 10% of all neonates with AATD develop liver disease, and about 3% overall progress to severe disease. AATD is a principal genetic