Phenotypic expression time of mutagen-induced 6-thioguanine resistance in Chinese hamster ovary cells (CHO/HGPRT system): Expression in division-arrested cell cultures

Expression of tumor suppressor p53 facil

Expression of tumor suppressor p53 facilitates DNA repair but not UV-induced G2/M arrest or apoptosis in Chinese hamster ovary CHO-K1 cells

✍ Yu-Ching Chang; Chu-Bin Liao; Pei-Yu Chiang Hsieh; Ming-Li Liou; Yin-Chang Liu 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 353 KB

## Abstract Tumor suppressor p53 is an essential regulator in mammalian cellular responses to DNA damage including cell cycle arrest and apoptosis. Our study with Chinese hamster ovary CHO‐K1 cells indicates that when p53 expression and its transactivation capacity was inhibited by siRNA, UVC‐induc