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Phenotypic expression of factor H mutations in patients with atypical hemolytic uremic syndrome

✍ Scribed by Vaziri-Sani, F; Holmberg, L; Sjöholm, A G; Kristoffersson, A-C; Manea, M; Frémeaux-Bacchi, V; Fehrman-Ekholm, I; Raafat, R; Karpman, D


Book ID
110052546
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
280 KB
Volume
69
Category
Article
ISSN
0085-2538

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Atypical hemolytic uremic syndrome (aHUS) is characterized by acute renal failure, thrombocytopenia and microangiopathic hemolytic anemia, and occurs with an estimated incidence in the USA of 2 per 1,000,000. Disease pathogenesis is related to dysregulation of the alternative pathway (AP) of the com