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Phenotypic classification of human CD8+ T cells reflecting their function: inverse correlation between quantitative expression of CD27 and cytotoxic effector function

✍ Scribed by Hiroko Tomiyama; Hiroshi Takata; Tomoko Matsuda; Masafumi Takiguchi


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
444 KB
Volume
34
Category
Article
ISSN
0014-2980

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## Abstract IL‐27 has been shown to exhibit both pro‐ and anti‐inflammatory properties; it favors mouse naïve CD4^+^T‐cell differentiation into Th1 cells to the detriment of Th17 and Th2 skewing and regulates IL‐10 and IL‐17 production by human CD4^+^ T cells. Moreover, IL‐27 promotes proliferation