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Phenotypic characterization of chromosome 14-linked familial Alzheimer's disease

✍ Scribed by Westermeyer, Joseph; Yoon, Gihyun; Tomaska, Julie; Kuskowski, Michael A.

Book ID
124121553
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
384 KB
Volume
15
Category
Article
ISSN
0197-4580

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Early onset familial Alzheimer's disease (AD) has an autosomal dominant mode of inheritance. T w o genes are responsible for the majority of cases of this subtype of AD. Mutations in the P-amyloid precursor protein (PAPP) gene on chromosome 21 have been shown to completely cosegregate with the disea