Phenotypic characteristics of cells involved in induced suppression to murine experimental autoimmune thyroiditis

✍ Scribed by Nicole M. Parish; Ivan M. Roitt; Anne Cooke

• Book ID: 102824278
• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 526 KB
• Volume: 18
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830180924

✦ Synopsis

Suppression of induced experimental autoimmune thyroiditis can be consistently transferred with spleen cells to syngeneic recipients, provided they are first treated with 200 rads irradiation. Treatment with anti-Thy-1 in vivo immediately prior to transfer abrogates the suppression, while depleting B cells has no effect.The in siru induced tolerance can be prevented by treatment with monoclonal antibodies to the Ly-1 or L3T4 molecules either prior to or post tolerization. Anti-Ly-2 treatment has no effect. In the transfer, again treatment of donors with anti-L3T4 prior to transfer prevents the demonstration of suppression in the recipients, while anti-Ly-2 does not affect suppression. These data suggest that the suppression is being mediated either by a CD4' T suppressor cell or a CD4' suppressor inducer cell. Preliminary experiments do not support the possiblity of a CD8' suppressor cell being activated in the recipient.