Phenotypes of placental-type alkaline phosphatase in seminoma sera as defined by monoclonal antibodies

✍ Scribed by B. Wahren; J. Hinkula; T. Stigbrand; A. Jeppsson; L. Andersson; P. L. Esposti; F. Edsmyr; J. L. Millán

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: French
• Weight: 543 KB
• Volume: 37
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910370419

✦ Synopsis

PLAP-like enzymes could be detected in serum of patients with primary testicular tumors, in particular seminomas. The use of a panel of monoclonal antibodies (MAbs) permitted typing into 6 different testicular serum phenotypes, of which one appeared similar to a placental type (11) and 2 have not been previously described. Most tumor sera belonged to type I, as described for seminoma tissues. With a more advanced tumor the mean serum PLAP-like levels increased. After operation, after radiotherapy or with no evidence of disease lower or non-detectable enzyme levels were found. In typing the tissue PLAPlike antigen in serum of the same patient or sera from recurrences of a seminoma in the same patient, the same phenotypes of PLAP-like antigen were usually but not always found. None of the 6 phenotypes appeared to confer a poorer prognosis. We conclude that the expression of PLAP-like antigen is eutopic and is enhanced by testicular malignancy, especially in serninoma cells.