Phenotype–genotype variability in the human CYP3A locus as assessed by the probe drug quinine and analyses of variant CYP3A4 alleles

Assessment of ifosfamide pharmacokinetic

Assessment of ifosfamide pharmacokinetics, toxicity, and relation to CYP3A4 activity as measured by the erythromycin breath test in patients with sarcoma

✍ Rashmi Chugh; Thomas Wagner; Kent A. Griffith; Jeremy M.G. Taylor; Dafydd G. Tho 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 190 KB

## Abstract ## BACKGROUND. Ifosfamide is a chemotherapeutic agent that requires cytochrome P450 3A (CYP3A) for bioactivation and metabolism. To the authors' knowledge, the correlation between dose, pharmacokinetics, CYP3A, and toxicity has not been fully evaluated. A randomized Phase II trial was