Phenotype modulation of human adult fibroblasts by oncogenes

✍ Scribed by Levy Kopelovich; Saba E. Demian

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 498 KB
• Volume: 15
• Category: Article
• ISSN: 0899-1987
• DOI: 10.1002/(sici)1098-2744(199603)15:3<163::aid-mc1>3.0.co;2-j

✦ Synopsis

THE IJ B IQU ITOUS FIB ROB LAST

Studies of the ubiquitous fibroblast have been instrumental in elucidating genetic determinants and susceptibility mechanisms in normal and diseased states [l-41. Thl: embryologic derivation of the fibroblast renders it capable of giving rise to a wide variety of phenotypic manifestations [ 5 ] . The mesoderm evolves into the putative mesoblast (prefibroblast). The mesoblast, under appropriate growth influences, differentiates into committed cells that include fibroblasts, myoblasts, adipoblasts, and still other cell types such as osteoblasts, chondroblasts, endothelial cells, and hemopoietic cells [5].

This report focuses largely on work from our laboratory. The main objectives of this report are (i) to illustrate the phienotypic potential of human adult fibroblasts,, (ii) to illustrate the role of oncogenes in the normal differentiation processes of human adult fibroblasts, and (iii) to discuss the implications regarding the role of human adult fibroblasts in oncogene-induced differentiation processes.