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Phenotype and functional analysis of human monocyte-derived dendritic cells loaded with biodegradable poly(lactide-co-glycolide) microspheres for immunotherapy

✍ Scribed by Ying Waeckerle-Men; Elke Scandella; Edith Uetz-von Allmen; Burkhard Ludewig; Silke Gillessen; Hans P. Merkle; Bruno Gander; Marcus Groettrup

Book ID: 113716746
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 665 KB
Volume: 287
Category: Article
ISSN: 0022-1759
DOI: 10.1016/j.jim.2004.01.010

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Dendritic cells (DCs) play a major role in development of cell-mediated immunotherapy due to their unique role in linking innate and adaptive immunities. In spite of improvement in this area, strategies employing ex vivo generated DCs have shown limited efficacy in clinical trials. Dendrimers have b