✦ LIBER ✦

Phenotype 2 of deoxyribonuclease I may be Used as a risk factor for gastric carcinoma

✍ Scribed by Souichi Tsutsumi; Takayuki Asao; Yukio Nagamachi; Tamiko Nakajima; Toshihiro Yasuda; Koichiro Kishi

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 76 KB
Volume: 82
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19980501)82:9<1621::aid-cncr4>3.0.co;2-d

No coin nor oath required. For personal study only.

✦ Synopsis

Background:

Human deoxyribonuclease i (dnase i) (ec3.1.21.1) is one of the candidate nucleases that acts in mammalian cells during apoptosis. genetic polymorphism of dnase i has been classified into 15 phenotypes controlled by 5 autosomal codominant alleles. the purpose of this study was to determine whether dnase i polymorphism is closely related to the incidence of gastric carcinoma.

Methods:

The phenotype distribution was examined using urine samples obtained from unrelated japanese patients with gastric carcinoma (n = 97) and benign gastric diseases (n = 76). phenotyping was performed using isoelectric focusing electrophoresis in thin polyacrylamide gel and immunoblotting with an antihuman dnase i antibody.

Results:

A close statistical association was found between patients with gastric carcinoma and a high frequency of dnase i phenotype 2. however, there was no significant difference in the phenotype distribution between the group of patients with benign gastric diseases and the controls.

Conclusions:

The findings of the current study suggest that dnase i phenotype 2 may be a marker for gastric carcinoma. therefore, compared with other phenotypes, dnase i phenotype 2 may have potential for identifying patients who are at risk of harboring or developing gastric carcinoma.

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