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Phenones: A family of compounds broadly applicable to use as internal standards in high-performance liquid chromatography : Application to the analysis of carbofuran

✍ Scribed by E.J. Kikta; A.E. Stange


Book ID
104145280
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
307 KB
Volume
138
Category
Article
ISSN
1873-3778

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✦ Synopsis


Phenones have been employed in high-performance liquid chromatography (HPLC) as a series of compounds forming a rational series of internal standards. It is shown. that they are useful in systems as polar as methanol-water (1 :l) and in systems as non-polar as methylene chloride-hexane (1:9). The potential in using a stable series of internal standards for many HPLC systems leading to improved quantitative precision and accuracy is discussed_ An application to the analysis of carbofuran, a broad-spectrum insecticide-nematicide, is described and disc&e& . . -


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## Abstract A fast, sensitive and specific method is presented for the quantification of RSD921 in human plasma by liquid chromatography coupled with tandem mass spectrometry using tri‐deuterated RSD921 (3d‐RSD921) as an internal standard. A single‐step liquid/liquid extraction was performed with d