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Phenobarbital-Elicited Activation of Nuclear Receptor CAR in Induction of Cytochrome P450 Genes

โœ Scribed by Igor Zelko; Masahiko Negishi

Book ID
115586637
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
168 KB
Volume
277
Category
Article
ISSN
0006-291X

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โœ Jose Chianale; Leyna Mulholland; Peter G. Traber; Jorge J. Gumucio ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 635 KB

Phenobarbital induces liver cytochrome P-450 b,e proteins mainly by increasing the rate of transcription of these genes. The mechanism responsible for the phenobarbital increment in the rate of transcription of cytochrome P-450 b,e genes is unknown. The objective of this study was to assess whether