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PHENAZONE POTENTIATES THE LOCAL ANAESTHETIC EFFECT OF LIDOCAINE IN MICE

✍ Scribed by MARC VERLEYE; ISABELLE HEULARD; JEAN-MARIE GILLARDIN

Book ID
118770804
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
123 KB
Volume
41
Category
Article
ISSN
1043-6618

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The pharmacokinetics of pentacaine, a new local anaesthetic agent from the group of carbanilates, was investigated in the rat at a dose of 2mg kg-I i.v. and per 0s. A three-compartment open model gave the best fit to the data. The model parameters are: flI2 99.0 k 14.lmin, V,, 7411.1ml kg-I, C1 77.9