Phenacylsulfonylacetic esters — source for thiadiazoles, triazoles and oxadiazoles
✍ Scribed by Venkatapuram Padmavathi; Pinnu Thriveni; Boreddy Chandra Obula Reddy; Konda Mahesh
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2007
- Tongue
- English
- Weight
- 403 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-152X
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✦ Synopsis
A new class of thiadiazoles, triazoles and oxadiazoles were prepared from phenacylsulfonylacetic ester by protecting the carbonyl group by oximation. Deoximation was affected by using -cyclodextrin in the presence of an oxidizing agent.
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## Abstract magnified image A new and novel five membered heterocycles thiadiazoles, oxadiazoles and triazoles were prepared from methyl 4‐arylsulfonyl‐3‐arylbutyrate and methyl 4‐arylmethanesulfonyl‐3‐arylbutyrate.
## Abstract magnified image A new class of 1,2,3‐selena/thiadiazoles and 2__H__‐diazaphospholes were synthesized by exploiting α‐ketomethylene group in phenacylsulfonylacetic acid methyl ester.
## Abstract Several 1‐(1‐aryl‐1,4‐dihydro‐3‐carboxy‐6‐methylpyridazin‐4‐one)‐4‐aryl thio‐semicarbazides and their corresponding oxadiazole, thiadiazole and triazole derivatives were prepared and characterized by their spectral data. The preliminary biological tests showed that some new compounds ex