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Phase-transfer-catalyzed asymmetric Darzens reaction

✍ Scribed by Shigeru Arai; Yoshiki Shirai; Toshimasa Ishida; Takayuki Shioiri

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 794 KB
Volume: 55
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(99)00213-6

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✦ Synopsis

Catalytic asymmetric Darzens reaction promoted by a chiral phase-transfer catalyst derived from cinchonine is described. The desired o~,[I-epoxy ketones were obtained by use of ct-chloro acyclic and cyclic ketones as substrates with moderate to high enantiomeric excesses under mild reaction conditions. This methodology can be quite an effective protocol for practical asymmetric synthesis.

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## Abstract For Abstract see ChemInform Abstract in Full Text.

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