Phase transfer catalysis: some recent applications in organic synthesis

✍ Scribed by Domenico Albanese; Dario Landini; Angelamaria Maia; Michele Penso

• Book ID: 104424596
• Publisher: Elsevier Science
• Year: 1999
• Tongue: English
• Weight: 452 KB
• Volume: 150
• Category: Article
• ISSN: 1381-1169
• DOI: 10.1016/s1381-1169(99)00219-8

✦ Synopsis

A survey dealing with the use of anhydrous potassium carbonate as an efficient base for promoting organic reactions Ž . under solid-liquid phase transfer catalysis SL-PTC conditions is reported. In particular, the generation in situ of trifluoroand trichloroacetamidide, and reactions of these azaanions with 2-bromocarboxylic esters and epoxides, affording protected a-amino acids and b-amido alcohols, respectively, are described. The reduction of allylic nitroderivatives with CS to 2 Ž . oximes or nitriles under SL-and liquid-liquid PTC LL-PTC is also presented. Finally, new preparation methods and a study of the reactivity of quaternary onium fluorides, hydrogendifluorides and dihydrogentrifluorides, together with the use of dihydrogentrifluorides as hydrofluorinating agents under SL-PTC conditions, are reported.