Phase-trafficking reagents and phase-switching strategies for parallel synthesis

✍ Scribed by Daniel L. Flynn

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 434 KB
• Volume: 19
• Category: Article
• ISSN: 0198-6325
• DOI: 10.1002/(sici)1098-1128(199909)19:5<408::aid-med7>3.0.co;2-j

✦ Synopsis

Strategies for the parallel synthesis of small molecule arrays are reviewed with an emphasis on those approaches that integrate the sciences of organic synthesis and product purification. The use of phase-tra fficking reagents (PTRs) and phase-switching strategies are highlighted, which allow the rapid, parallel synthesis of small molecule arrays with 'built-in' purification determinants.