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Phase I/II study of decitabine in patients with myelodysplastic syndrome: A multi-center study in Japan

โœ Scribed by Yasuhiro Oki; Yutaka Kondo; Kazuhito Yamamoto; Michinori Ogura; Masanobu Kasai; Yukio Kobayashi; Takashi Watanabe; Naokuni Uike; Kazuma Ohyashiki; Shin-ichiro Okamoto; Kazunori Ohnishi; Akihiro Tomita; Yasushi Miyazaki; Kaoru Tohyama; Harumi Y. Mukai; Tomomitsu Hotta; Masao Tomonaga

Book ID
117940889
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
320 KB
Volume
103
Category
Article
ISSN
1347-9032

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โœ Hagop Kantarjian; Jean-Pierre J. Issa; Craig S. Rosenfeld; John M. Bennett; Mahe ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 204 KB

## Abstract ## BACKGROUND Aberrant DNA methylation, which results in leukemogenesis, is frequent in patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic therapy. Decitabine indirectly depletes methylcytosine and causes hypomethylation of target gene promoters.