Phase II trial of VP16-213 in non-small cell lung cancer (NSCLC)
β Scribed by Robert Chapman; Loretta Itri; Richard Gralla; David Kelsen; Ephraim Casper; Robert Golbey
- Publisher
- Springer
- Year
- 1982
- Tongue
- English
- Weight
- 238 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0344-5704
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Twentyβthree patients with nonβsmall cell lung cancer were treated with a combination of cisβdichlorodiammineplatinum(II) 100 mg/m^2^ IV on day 1 and VP 16β213 80 mg/m^2^ IV on days 1β3. Eighteen patients are evaluable for response. Seven partial remissions with a median duration of 3 m
Forty-three previously untreated patients, all of whom had poor-prognosis small cell lung cancer and/or were greater than 65 years old, received treatment with vindesine and VP16-213. Thirteen patients had limited disease and 30 extensive disease. Response rates (CR + PR) of 86% (CR 29%) and 66% (CR
Small cell lung cancer requires aggressive combination chemotherapy. The three active agents, doxorubicin (A) 45 mg/m2 i.v. day 1, cyclophosphamide (C) 1.0 mg/m2 i.v. day 1 and VP16-213 (E) 50 mg/m2/day i.v. days 1-5 were given together. The combination (ACE) was given every 21 days without chest ir