𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Phase II trial of N-(phosphonacetyl)-l-aspartate (PALA), 5-fluorouracil and recombinant interferon-α-2b in patients with advanced gastric carcinoma

✍ Scribed by S. Wadler; B. Gleissner; R.U. Hilgenfeld; E. Thiel; H. Haynes; R. Kaleya; A. Rozenblit; E.-D. Kreuser


Book ID
116167865
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
377 KB
Volume
32
Category
Article
ISSN
0959-8049

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Phase II study of N-phosphonacetyl-L-asp
✍ Corey J. Langer; David Schaebler; Edward Sauter; Deborah DeMaria; Cheryl Johnson 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 79 KB 👁 2 views

## Background: 5-fluorouracil (5-fu), as a single agent, produces a 15% response rate in advanced squamous cell carcinoma of the head and neck (scchn). n-phosphonacetyl-l-aspartate (pala) inhibits pyrimidine biosynthesis and increases incorporation of 5-fu metabolites into ribonucleic acid (rna). r

Phase II clinical trial with 5-fluoroura
✍ Scott Wadler; Hilda Haynes; Jonathan J. Beitler; Xiaoping Hu; Stanley Fell; Marg 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 393 KB 👁 1 views

## Background: Recombinant interferon-alpha (ifn) augments the cytotoxicity of both 5-fluorouracil (5-fu) and cisplatin in vitro. a phase ii study of 5-fu and ifn resulted in response rates of 25-27% in patients with metastatic esophageal carcinoma. ## Methods: A phase ii trial was initiated to d

A Phase II trial of 5-fluorouracil and r
✍ Richard Pazdur; Jaffer A. Ajani; Rodger Winn; James Bearden; Robert J. Belt; Sus 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 468 KB 👁 3 views

A Phase I1 clinical trial of the combination of 5-fluorouracil (5-FU) and recombinant alpha-2a-interferon (a-2a-IFN) was conducted in 44 patients. Patients had not received chemotherapy previously and had measurable metastatic gastric carcinoma. 5-FU was administered as a continuous infusion at a do