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Phase II trial of carboplatin and infusional cyclosporine in platinum-resistant recurrent ovarian cancer

โœ Scribed by Robert J. Morgan; Timothy W. Synold; David Gandara; Franco Muggia; Sidney Scudder; Eddie Reed; Kim Margolin; James Raschko; Lucille Leong; Stephen Shibata; Merry Tetef; Steven Vasilev; Kathryn McGonigle; Jeff Longmate; Yun Yen; Warren Chow; George Somlo; Mary Carroll; James H. Doroshow

Publisher
Springer
Year
2004
Tongue
English
Weight
215 KB
Volume
54
Category
Article
ISSN
0344-5704

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## Abstract ## BACKGROUND: Aberrant DNA methylation is a hallmark of cancer, and DNA methyltransferase inhibitors have demonstrated clinical efficacy in hematologic malignancies. On the basis of preclinical studies indicating that hypomethylating agents can reverse platinum resistance in ovarian c