Phase II trial of 5-fluorouracil and low-dose cisplatin in patients with squamous cell carcinoma of the esophagus
β Scribed by Hiroyuki Sekiguchi; Seiji Akiyama; Michitaka Fujiwara; Hajime Nakamura; Ken Kondo; Yasushi Kasai; Katsuki Ito; Junichi Sakamoto; Hiroshi Takagi
- Book ID
- 112759769
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 76 KB
- Volume
- 29
- Category
- Article
- ISSN
- 1436-2813
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## Abstract ## BACKGROUND The current study evaluated the feasibility and clinical activity of a combination of paclitaxel, cisplatin, 5βfluorouracil (5βFU), and leucovorin administered on a biweekly schedule to patients with recurrent or unresectable squamous cell carcinoma of the head and neck (
Forty-four patients with advanced esophageal squamous cell carcinoma were treated with biochemical modulated combination chemotherapy and surgery. Treatment consisted of cisplatinum (70 mg/m 2 /day 1, day 22), 5-fluorouracil (5-FU; 700 mg/m 2 /day, days 1-5, 22-26), and leucovorin (20 mg/m 2 /day, d