## BACKGROUND. Advanced unresectable pancreatic adenocarcinoma has a dismal prognosis. The authors previously have shown that retinoic acid (RA) and interferon-␣ (IFN-␣) inhibit growth and induce differentiation in human pancreatic carcinoma cells in vitro and in vivo. The purpose of this trial wa
Phase II trial of 13-cis-retinoic acid plus interferon-α in recurrent head and neck cancer
✍ Scribed by Narin Voravud; Scott M. Lippman; Randal S. Weber; Gladys I. Rodriquez; Douglas Yee; Isaiah W. Dimery; Charles L. Earley; Daniel D. Hoff; Waun Ki Hong
- Publisher
- Springer US
- Year
- 1993
- Tongue
- English
- Weight
- 337 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0167-6997
No coin nor oath required. For personal study only.
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## BACKGROUND. Interferon in combination with 5-fluorouracil has been shown to be active in squamous cell carcinoma (SCC) and adenocarcinoma (AC) of the esophagus. 13-cis-retinoic acid (CRA) has chemopreventive activity in SCC of the head and neck, and, in combination with interferon, has antitumo
It is well known that survival of patients with advanced squamous-cell carcinoma of the head and neck (SCCHN) has not significantly improved despite recent advances in radiation and chemotherapy treatment. Specifically, a very low objective response rate can be obtained in patients with recurrent SC