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Phase-II study of weekly schedule of trastuzumab, paclitaxel, and carboplatin followed by a week off every 28

✍ Scribed by M. Ruiz; J. Salvador; J. Bayo; M. Lomas; A. Moreno; M. Valero; R. Bernabé; D. Vicente; J. Jiménez; A. Lopez-Ladrón

Book ID: 105992863
Publisher: Springer
Year: 2008
Tongue: English
Weight: 245 KB
Volume: 62
Category: Article
ISSN: 0344-5704
DOI: 10.1007/s00280-008-0709-7

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## Background: We conducted a phase i study of weekly paclitaxel (p) and carboplatin (c) in patients with advanced malignancies to determine the maximum tolerated dose (mtd) of this combination. ## Methods: Dose levels were escalated independently for patients with and without previous chemothera