Phase II study of tiazofurin in gliomas in adults
β Scribed by David J. Stewart; Elizabeth Eisenhauer; David R. Macdonald; J. Gregory Cairncross; Adrian Langleben
- Publisher
- Springer US
- Year
- 1993
- Tongue
- English
- Weight
- 328 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0167-594X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Forty adults with recurring brain gliomas were treated with HECNU 130 mg/m 2, given i.v. every 5 to 6 weeks (mean 5.4) and corticosteroids. According to the response to treatment, patients were divided in 3 groups: 1. Group I included 8 pts (20%) with objective remission, defined as a clear-cut clin
## Abstract ## BACKGROUND In the current study, the authors report a Phase II trial of irinotecan (CPTβ11), a topoisomerase I inhibitor active against malignant glioma (MG), with celecoxib, a selective COXβ2 inhibitor, among MG patients with recurrent disease. ## METHODS Patients with MG at any
Fourteen evaluable patients with small cell bronchogenic carcinoma received tiazofurin, an inhibitor of inosine monophosphate dehydrogenase, that progressed after one combination chemotherapy. No objective remission was observed at the dosage of 800 mg/m2 for 5 consecutive days. Toxicity was moderat