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Phase II study of imatinib mesylate and hydroxyurea for recurrent grade III malignant gliomas

✍ Scribed by Annick Desjardins; Jennifer A. Quinn; James J. Vredenburgh; Sith Sathornsumetee; Allan H. Friedman; James E. Herndon; Roger E. McLendon; James M. Provenzale; Jeremy N. Rich; John H. Sampson; Sridharan Gururangan; Jeannette M. Dowell; August Salvado; Henry S. Friedman; David A. Reardon


Publisher
Springer US
Year
2007
Tongue
English
Weight
162 KB
Volume
83
Category
Article
ISSN
0167-594X

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## Abstract ## BACKGROUND. The prognosis for patients with recurrent high‐grade gliomas is poor and treatment options are limited. Current chemotherapeutic regimens can improve clinical outcomes, but extend survival by only a few months. Temozolomide is a methylating agent that is typically admini