Phase II study of high-dose epirubicin, lonidamine, alpha 2b interferon in advanced breast cancer
β Scribed by Rosario Vincenzo Iaffaioli; Anna Tortoriello; Gaetano Facchini; Michele Santangelo; Luigi Bucci; Landino Fei; Natale Martino; Giovanni Mantovani; Francesco Caponigro
- Publisher
- Springer US
- Year
- 1995
- Tongue
- English
- Weight
- 545 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0167-6806
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## BACKGROUND. Anthracyclines are among the most active drugs in the treatment of breast carcinoma and exhibit a steep dose-response curve in vitro. This trial was performed to determine the efficacy and toxicity of epirubicin in the treatment of patients with advanced breast carcinoma when adminis
Twenty-three evaluable patients with advanced breast cancer were treated with MPA, 1,400 mg/m2 daily PO for the first 6 months, and 500 mg/m2 daily PO thereafter. The median total dose was 191,400 mg in 88 days, with the maximum dose given to date 522,600 mg in 282 days. Most patients tolerated high