Phase II study of carboplatin (CBDCA) in refractory multiple myeloma
โ Scribed by Bart Barlogie; John Crowley; Sydney E. Salmon; John Bonnet; James K. Weick; Kathy Hayden
- Publisher
- Springer US
- Year
- 1994
- Tongue
- English
- Weight
- 233 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0167-6997
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
In a phase II trial, 16 patients with relapsed refractory multiple myeloma received temsirolimus 25mg I.V. weekly until progression. One partial response and 5 minor responses were observed for a total response rate of 38%. The median time to progression was 138 days. Grade 3-4 toxicity included fat
5-azacytidine (5-AZA) and carboplatin (CBDCA) are two agents which have demonstrated antileukemic activity In a number of phase 1-11 trials. Their mechanisms of action and pharmacology related to cell resistance suggested sultabiiity for combination therapy. The aim of this pilot study was to evalua
Seventy-four previously treated patients with multiple myeloma were treated with Amsacrine (m-AMSA) 120 mg/m2 every 3 weeks. A good response was observed in two patients (3%), and improvement was seen in three patients (4%). Severe toxicity was observed in 33% of patients who received three or more